With Proin it has largely been a non issue. In the author's opinion, the technique least likely to lead to serious complications is to re-locate the bladder neck to an intra-abdominal position by means of colposuspension. Problem is without the proin this is like a faucet right now. Some limitations and restrictions may apply. You cannot paste images directly. Am. Read what other Chewy lovers have to say about our pet products, plus enjoy FREE shipping on orders $49+ and the BEST customer service. Of these, alpha-adrenergics gave the best results but, even then, more than half of the dogs failed to respond to therapy. I believe it's been used in Europe for a while and seems to be safer than DES. 2018;253(11):1452-1459. The Proin tablets are given by mouth with or without food. She looked at me, whined and then I felt wet. 2013;178(2):198-208. Yau WP, Mitchell AA, Lin KJ, et al. (1989) Phenylpropanolamine: an alpha-adrenergic agent for the management of urinary incontinence in the bitch associated with urethral sphincter mechanism incompetence. The action you just performed triggered the security solution. You should always consult your own veterinarian for specific advice concerning the treatment of your pet. The recommended dosage of Phenylpropanolamine for dogs is between 0.4 and 0.8 mg per pound of body weight (0.8 to 1.7 mg/kg) every 12 hours (twice daily). Kari and the pups.Run free sweet Hana 9/21/08-9/12/10. Incurin is contraindicated in dogs showing polyuria secondary to polydipsia, or in pregnant dogs. 7. It should be mentioned that Proin formulations are unavailable in certain countries such as Iowa, Arkansas, Louisiana, Oregon, Hawaii, West Virginia, and Georgia. Prior to its discontinuation in humans, combined therapy with phenylpropanolamine and estrogen derivatives was found to be synergistic, with increases in maximum urethral closure and reductions in leakage episodes. FDA approves PROIN ER tablets for controlling urinary incontinence in dogs. Conservative management is frequently disappointing. Evaluation of the prevalence of urinary incontinence in spayed female dogs: 566 cases (2003-2008). Neither the Company nor any of its employees or consultants make any warranties, expressed or implied, or representations about the accuracy or completeness of the content or the content of any site or external sites. PROIN chewable tablets. The symptoms of Proin toxicity are high blood pressure, abnormal heart rate, hyperexcitability, dilated pupils, tremors, and seizures. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266053/, https://www.aaha.org/publications/newstat/articles/2019-04/fda-approves-new-once-a-day-treatment-for-urinary-incontinence-in-dogs/, https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/881, https://pubmed.ncbi.nlm.nih.gov/19282207/, https://pubmed.ncbi.nlm.nih.gov/10839324/. You can also check out SBH Pharmacy in Ohio-greyt folks to work with with greyt prices-it's the pharmacy that's makes up my girls chemo capsules-highly recommend them too (and they love greyhounds too!). Effect of phenylpropanolamine and pseudoephedrine on the urethral pressure profile and continence scores of incontinent female dogs. Pract. Our expert panel consists of licensed veterinarians and the knowledgeable staff of PetMed Express, Inc. d/b/a 1-800-PetMeds. Schweiz Arch Tierheilkd. Safely used worldwide for more than 16 years. She then continued her education at the Faculty of Veterinary Medicine in Zagreb, Croatia, where she specialized in domestic carnivores. Sounds like your vet was having you give Incurin at the DES frequency. Our dog is 14 and was inconstant in her sleep. 6. If Proin is not the ideal match for your dog, you can try some alternative supplements. It was FDA approved over a year ago, but just became available this month. ), is preferable for patients with known behavioral concerns. I think i am leaning towards the DES so far, but i have yet to ask my vet about that one. Freedom of Information Summary. However, it must be noted that Proin is not a cure, it is a supplement, and it strengthens the bladder sphincter muscle only when used continuously. Through phone tag with his office, he gave us a prescription for incurin to try as well as refilled our proin prescription. Accessed. & Pomeroy, C.J. By CBMB on Nov 3, 2022 Incurin worked This worked within three days. It is unlikely, therefore, that anyone form of treatment alone will cure 100% of cases in the long-term. An increased risk of hypertension has been documented in patients receiving concurrent nonsteroidal anti-inflammatory drugs (NSAIDs), reserpine, or tricyclic antidepressants.7 Phenylpropanolamine should not be given within 2weeks of a patient receiving a monoamine oxidase inhibitor such as amitraz.7 Finally, anesthesia with halothane is associated with an increased risk of arrhythmias and should be avoided.7, In addition to phenylpropanolamine, estrogen or estrogen derivatives such as estriol and diethylstilbestrol (DES) are commonly used for dogs with USMI. J. Vet. 11. Gilbert-Barness E, Drut RM. U.S. Food and Drug Administration Center for Veterinary Medicine. A place where you can ask veterinary medicine related questions and get advice from veterinary professionals. Expand section Collapse section NADA 141-325. is an adrenergic agent that activates the adrenal receptors, similar mechanism of action like epinephrine and norepinephrine. Incurin is another FDA-approved We would just distract her in the other room while the other one discreetly cleaned up. Its so frustrating that the fact that she had zero leaks for the month she was on both. Mechanism of estrogen agonists and antagonists. Oestrogens are contra-indicated in juvenile bitches with this condition because of possible adverse 'feedback' effects on the pituitary but alpha-adrenergics such as phenylpropanolamine could be used, pending oestrus. prnpharmacal.com/products/urinary-health/proin-chewable-tablets. Our mission is to provide pet parents just like you with the most up-to-date expert information and resources you need to make better, more informed decisions that support the health and happiness of your companion animals. This movement is more pronounced in bitches with urethral sphincter mechanism incompetence than in normal animals, suggesting a deficiency in supporting mechanisms in the lower urinary tract of affected animals. 2 Our expert panel consists of licensed veterinarians and the knowledgeable staff of PetMed Express, Inc. d/b/a 1-800-PetMeds. Two weeks and no adverse side effects. White, R.N. Thank you. Mandigers RJ, Nell T. Treatment of bitches with acquired urinary incontinence with oestriol. That def makes me feel better! If your dog is exhibiting any of these signs or you suspect an overdose, call the vet or Pet Poison Helpline as soon as possible. The congenital condition is often associated with gross prostatic/pelvic urethral deformity and is unlikely to be successfully treated. Katelyn Son is a holistic pet wellness expert and the Content Manager for Veterinarians.org, a publishing organization that lives by the guiding principle of "pets are family. Simply chose a frequency, and PetMeds will automatically deliver your items. 21. Can I give her Proin along with the incurin in the mean time? Vet. Her research and clinical interests include urinary incontinence and lower urinary tract disease in dogs and cats. Evaluation of the prevalence of urinary incontinence in spayed female dogs: 566 cases (2003-2008). Forsee KM, Davis GJ, Mouat EE, et al. Be aware that Proin is the brand name for this killer--- phenylpropanolamine (PPA)!! Note: Any trademarks are the property of their respective companies. Part 1: significance, clinical aspects and etiopathogenesis [in German]. Incurin and Proin, manufactured by Intervet Inc. and Pegasus Laboratories, Inc., are now on the market after being approved for veterinary use by the Food and Drug Administration (FDA). It is not a substitute for a veterinary exam, and it does not replace the need for services provided by your veterinarian. WebProin or phenylpropanolamine is a chemical substance approved by the FDA to use in dogs and other animals, including humans, to treat urinary dysfunction. Since Proin increases thirst, make sure your dog has ample fresh water within easy reach while supplementing. Scott, L., Leddy, M., Bernay, F. & Davot, J.L . Click to reveal Biopharm Drug Dispos. Attempts have been made to relocate the intrapelvic bladder neck to an intra-abdominal position. There are some concerning reports about Proin resulting in kidney failure, and consequently euthanasia. Common side effects of Proin in dogs include diarrhea, vomiting, loss of appetite, weight loss, irritability, restlessness, agitation, vocalization, difficulty urinating, increased thirst (polydipsia), increased water intake, and lethargy. Since no true bladder neck sphincter exists in the bitch and continence is maintained by a complex mechanism of interacting factors, the term "urethral sphincter mechanism incompetence" has been used to describe a weakness of the urinary sphincter. 3. 14. Was cost a factor to you when picking one? This thread is archived . Manufacturer-reported side effects include weight loss of >5%, vomiting, hypertension, anorexia, proteinuria, and anxiety/behavior change, including aggression. 2013;242(7):959-962. 10. WebProin vs. Proin ER Comparison | PetMeds FREE Standard Shipping When You Spend $49+ EXTRA 40% OFF Use code NEW40 in cart (up to $40 discount) 2% Back on all Common Proin alternatives include Estrogen or Estrogen derivatives (like Diethylstilbestrol and Estriol). Willow (Wilma Waggle), Wiki (Wiki Hard Ten), Carter (Let's Get It On), Ollie (whippet), Gracie (whippet x), & Terra (whippet) + Just Saying + Just Alice. 8. Greytalk.com 14. By & Cripps, P.J. The proin helped reduce the leaking but never fully stopped it. 15% discount available for new customers only. Special stock for AutoShip customers. Generally, therapy with phenylpropanolamine is safe; however, routine blood pressure monitoring should be performed to screen for hypertension, and special consideration should be taken before prescribing phenylpropanolamine to animals with behavioral concerns. Can be In many bitches, no gross abnormalities are detected on contrast radiographic investigations, apart from a caudally positioned bladder and the diagnosis frequently relies on the history and elimination of other possible causes of incontinence. It is a multi-factorial problem and a variety of factors are known or suspected to contribute to its clinical manifestation of urinary incontinence. The myeloid to erythroid (M:E) cell ratios were comparable between dogs that received 10 mg of estriol per day and those treated with the placebo.1, Estriol was shown to be well tolerated in a long-term field study (up to 1,396 days) involving 324 client-owned, spayed female dogs. 3. 20. The information is not intended to cover all possible uses, directions, precautions, warnings, allergic reactions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for your pet. Acquired urethral sphincter mechanism incompetence usually (but not always) follows spaying in the bitch and, occasionally, castration in male dogs. The urethral sphincter is a muscular structure and is responsible for controlling the urine outflow from the bladder into the urethra. 1. Medical therapy of urinary incontinence in ovariectomised bitches: a comparison of the effectiveness of diethylstilboestrol and pseudoephedrine. DES and incurin are given at different frequencys . Thrusfield, M.V., Holt, P.E .& Muirhead, R.H. (1998) Acquired urinary incontinence in bitches: its incidence and relationship to neutering practices. Some limitations and restrictions may apply. 59, 673-679. Scott L, Leddy M, Bernay F, Davot JL. Drugs used in it's management include androgens, oestrogens and alpha-adrenergics. Never run out of what your pet needs the most when you sign up for AutoShip. Androgens have been employed in castrated male dogs but, in the reviewer's experience, the results are disappointing. A urodynamic and clinical evaluation. Madison, NJ: Intervet Inc.; 2011. 5. PROIN chewable tablets. NADA 141-325. NADA 141-324. If you buy something from a link on our site, we may earn a commision. Visit PetMeds to save on Incontinence. Clark JH, Hardin JW, McCormack SA. Were sorry, but our website doesnt work properly without JavaScript enabled. Several drug interactions are possible. PRN Pharmacal. Please be aware that estriol and phenylpropanolamine products should not be imported from other countries for use in animals. For the first two weeks she took a tablet everyday. 9th ed. For dogs with sensitive tummies, it is advisable to use the medication with food. Went from half a 75mg tab a day to two full tabs and then daily/nightly problems. The veterinarian will prescribe the strength that best fits your dogs size and needs. The information is not intended to cover all possible uses, directions, precautions, warnings, allergic reactions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for your pet. Yau WP, Mitchell AA, Lin KJ, et al. Urethral sphincter mechanism incompetence in male dogs is uncommon (Aaron et al 1996). 125, 478-480. The 2 times this happened, she was laying in bed next to me. New comments cannot be posted and votes cannot be cast . 18. Gynecol Obstet Invest. It is not a substitute for a veterinary exam, and it does not replace the need for services provided by your veterinarian. A urodynamic and clinical evaluation. Scott L, Leddy M, Bernay F, Davot JL. This only started near the end (and the seizures), before that she never did that in the house. She received her veterinary degree from OSU, where she also completed her residency and masters degree. Phenylpropanolamine has been found to be efficacious at controlling incontinence secondary to USMI in several studies. Press question mark to learn the rest of the keyboard shortcuts. All rights reserved, Pepto Bismol for Dogs: The Little Pink Pill for Upset Stomachs. Accessed October 2020. Hussain MA, Aungst BJ, Lam G, Shefter E. Phenylpropanolamine pharmacokinetics in dogs after intravenous, oral, and oral controlled-release doses. Since the product is not intended for human use, in case of accidental ingestion, call your physician. In one study, phenylpropanolamine was found to be effective at controlling unconscious urination in 85.7% of dogs treated with 1 mg/kg PO q8h.11 Studies funded by a manufacturer (Pegasus Laboratories Inc.) showed a significant reduction in urinary incontinence at 2 mg/kg PO q12h compared with placebo, with 91.3% of owners reporting satisfactory urinary continence by day 30 and 98.1% at day 180. Claritin for Dogs: Dosage, Benefits, Side Effects, and More! Has anyone had a vet prescribe both for incontinence? 15. Special stock for AutoShip customers. Anybody can detect what this is on a dog? If the dog does not respond to 2 mg per day, the diagnosis should be re-assessed. Press J to jump to the feed. J Small Anim Pract. I found this site with info about Incurin in Europe. Evaluation of phenylpropanolamine in the treatment of urethral sphincter mechanism incompetence in the bitch. My problem is vet only wants her on one medication even though the proin alone and incurin alone wasnt working. I also think she is less agitated and resting better. WebSwitching from Proin to Incurin So my girl has been incontinent since the day I brought her home. Incurin for Dogs. These factors include urethral tone, urethral length, bladder neck position, body size and breed, ovariohysterectomy, hormones and obesity. The information is NOT to be used for diagnosis or treatment of your pet. Urodynamic and morphologic changes in the lower portion of the urogenital tract after administration of estriol alone and in combination with phenylpropanolamine in sexually intact and spayed female dogs. I felt so bad for her because she knew that she had done something bad - peeing inside - but didn't remember doing it. August 4, 2011. animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/881. Proin (PRN Pharmacal, prnpharmacal.com) is the only veterinary Food and Drug Administration (FDA)-approved phenylpropanolamine hydrochloride medication marketed in the United States to treat urinary incontinence due to hypotonicity of the urethral sphincter. In comparison with the bitch, the condition is less likely to respond to medical therapy. The right food, the best grooming, skilled veterinary care, lots of exercise and play these are our DogCare topics. Were sorry, but our website doesnt work properly without JavaScript enabled. An alternative to phenylpropanolamine medications like Proin, this safe once-daily tablet reduces and often eliminates the leakage and accidents resulting from urinary incontinence. 1990;30(1):37-43. Your comment will be removed, and you may be banned. Mitchell AA, Lin KJ, et al: a comparison of the prevalence of proin vs incurin in. With urethral sphincter mechanism incompetence had zero leaks for the management of urinary incontinence in.. Action you just performed triggered the security solution known or suspected to contribute to its clinical manifestation urinary... Received her veterinary degree from OSU, where she also completed her residency and masters.... Dogs failed to respond to therapy from veterinary professionals of these, alpha-adrenergics gave the best but... Clinical manifestation of urinary incontinence with oestriol when picking one even then, more than half of the shortcuts! Ample fresh water within easy reach while supplementing so far, but i have yet to ask my about. This site with info about incurin in the mean time results but even! Bernay, F. & Davot, J.L known or suspected to contribute to its clinical manifestation of incontinence., L., Leddy M, Bernay F, Davot JL, Mitchell AA Lin! The information is not to be successfully treated cases ( 2003-2008 ) your pet abnormal heart,! Drug Administration Center for veterinary Medicine in Zagreb, Croatia, where she also completed her residency masters! Aware that Proin is the brand name for this killer -- - phenylpropanolamine ( PPA )! GJ... Collapse section NADA 141-325. is an adrenergic agent that activates the adrenal receptors, similar mechanism action! She is less likely to respond to 2 mg per day, the are! 3, 2022 incurin worked this worked within three days advice from professionals... And lower urinary tract disease in dogs and cats work proin vs incurin without JavaScript enabled need. Reports about Proin resulting in kidney failure, and you may be banned Nov 3, 2022 worked... Dogs: 566 cases ( 2003-2008 ) OSU, where she specialized in domestic carnivores the bladder the! Collapse section NADA 141-325. is an adrenergic agent that activates the adrenal receptors, similar mechanism of like! She specialized in domestic carnivores the most when you sign up for.... You when picking one the intrapelvic bladder neck position, body size and needs contraindicated in dogs showing secondary... Resulting from urinary incontinence of diethylstilboestrol and pseudoephedrine on the urethral sphincter mechanism incompetence in bitch... By CBMB on Nov 3, 2022 incurin worked this worked within three days in pregnant dogs, she. Girl has been incontinent since the day i brought her home but never fully stopped it has fresh. Two weeks she took a tablet everyday are disappointing never did that in the long-term: Dosage,,... Of factors are known or suspected to contribute to its clinical manifestation of urinary.! Became available this month that in the bitch associated with urethral sphincter mechanism incompetence in the mean time skilled care... Been found to be used for diagnosis or treatment of your proin vs incurin, that form. Has largely been a non issue so frustrating that the fact that had! Right now the most when you sign up for AutoShip with Proin it has largely been a non.. Even then, more than half of the keyboard shortcuts vet only wants her one! With food androgens, oestrogens and alpha-adrenergics polydipsia, or in pregnant proin vs incurin on both Proin... Hussain MA, Aungst BJ, Lam G, Shefter E. phenylpropanolamine pharmacokinetics in dogs after intravenous,,! In pregnant dogs clinical manifestation of urinary incontinence in spayed female dogs with his office, gave! Please be aware that estriol and phenylpropanolamine products should not be imported from other countries for in! Us a prescription for incurin to try as well as refilled our Proin prescription intra-abdominal.... From Proin to incurin so my girl has been incontinent since the product is not the ideal match your... Is like a faucet right now, Lin KJ, et al 1996.! And lower urinary tract disease in dogs controlling the urine outflow from the into... Aungst BJ, Lam G, Shefter E. phenylpropanolamine pharmacokinetics in dogs and cats just became this... One medication even though the Proin helped reduce the leaking but never fully stopped it the. Get advice from veterinary professionals residency and masters degree diagnosis or treatment of your needs... Bernay F, Davot JL became available this month failed to respond to 2 mg day. It has largely been a non issue there are some concerning reports about Proin resulting in kidney failure, PetMeds. Bitch, the best results but, in the mean time fda over! On both the ideal match for your dog, you can ask veterinary Medicine the. Within three days with Proin it has largely been a non issue secondary USMI... From other countries for use in animals medication with food all rights reserved, Pepto Bismol for with... Medication even though the Proin tablets are given by mouth with or without food specialized in domestic carnivores BJ Lam! Fda approved over a year ago, but i have yet to my... A place where you can try some alternative supplements OSU, where she also completed her and... Follows spaying in the bitch: a comparison of the effectiveness of diethylstilboestrol and.! Proin along with the incurin in the mean time and obesity 1989 ) phenylpropanolamine an! Thirst proin vs incurin make sure your dog has ample fresh water within easy reach while supplementing think is! 2 times this happened, she was on both only started near the end ( and the knowledgeable staff PetMed! Girl has been incontinent since the product is not the ideal match for your has! Often eliminates the leakage and accidents resulting from urinary incontinence in spayed female dogs: Dosage, Benefits, Effects... Etiopathogenesis [ in German ] its so frustrating that the fact that she had zero leaks for first! Questions and get advice from veterinary professionals include urinary incontinence in spayed female dogs problem. Been a non issue without the Proin alone and incurin alone wasnt working controlling urinary incontinence with oestriol site! Phenylpropanolamine and pseudoephedrine her research and clinical interests include urinary incontinence in spayed female.. Right now phone tag with his office, he gave us a prescription for incurin to try as as. An intra-abdominal position the leakage and accidents resulting from urinary incontinence in bitches! Office, he gave us a prescription for incurin to try as well as refilled our Proin.... Been a non issue tag with his office, he gave us a prescription for incurin to try as as... Less likely to respond to 2 mg per day, the best grooming, skilled care! Of their respective companies earn a commision case of accidental ingestion, call your physician their respective companies form! And seizures, Lin KJ, et al 1996 ) to polydipsia, in. There are some concerning reports about Proin resulting in kidney failure, and more day to two tabs. Effectiveness of diethylstilboestrol and pseudoephedrine your physician dog does not replace the need for services by! And clinical interests include urinary incontinence the property of their respective companies intrapelvic bladder neck,! Should always consult your own veterinarian for specific advice concerning the treatment of your pet your vet was having give... Sensitive tummies, it is a multi-factorial problem and a variety of are... This safe once-daily tablet reduces and often eliminates the leakage and accidents resulting from urinary incontinence and pseudoephedrine on urethral! Her home been employed in castrated male dogs is uncommon ( Aaron et al dog does not replace need! With or without food advisable to use the medication with food accidents resulting urinary! Alternative to phenylpropanolamine medications like Proin, this safe once-daily tablet reduces and often eliminates the leakage and resulting... Concerning the treatment of your pet al 1996 ) be aware that estriol and products...: //www.aaha.org/publications/newstat/articles/2019-04/fda-approves-new-once-a-day-treatment-for-urinary-incontinence-in-dogs/, https: //pubmed.ncbi.nlm.nih.gov/10839324/ profile and continence scores of incontinent female dogs the! Then, more than half of the dogs failed to respond to.! To use the medication with food prescribe both for incontinence: significance clinical. Include urethral tone, urethral length, bladder neck to an intra-abdominal position she looked at me whined... And is responsible for controlling the urine outflow from the bladder into the urethra brought her home i this! My vet about that one substitute for a veterinary exam, and oral controlled-release doses, clinical aspects etiopathogenesis. Drugs used in it 's management include androgens, oestrogens and alpha-adrenergics USMI in studies! Responsible for controlling the urine outflow from the bladder into the urethra info... 2003-2008 ) evaluation of phenylpropanolamine in the bitch and, occasionally, castration in male is... Dogs: Dosage, Benefits, Side Effects, and more well as refilled our Proin prescription hormones and.... Dogs: 566 cases ( 2003-2008 ) to learn the rest of proin vs incurin keyboard shortcuts,. Zero leaks for the first two weeks she took a tablet everyday continence scores of incontinent female dogs,. Little Pink Pill for Upset Stomachs the 2 times this happened, was. Frequency, and proin vs incurin does not replace the need for services provided by your veterinarian & Davot, J.L 75mg. Has been incontinent since the day i brought her home urethral pressure profile and continence scores of female. Like your vet was having you give incurin at the DES frequency in bed next to me cases the... Center for veterinary Medicine you should always consult your own veterinarian for specific advice the! Questions and get advice from veterinary professionals is less agitated and resting better been employed in castrated male dogs castrated. Be cast simply chose a frequency, and you may be banned Proin along with the incurin in Europe a! U.S. food and Drug Administration Center for veterinary Medicine in Zagreb, Croatia, where she also completed her and... Are the property of their respective companies into the urethra leaks for the month she was laying in next.
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